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Hepatitis C is a viral disease that leads to swelling (inflammation) of the liver.
Non-A hepatitis; Non-B hepatitis
Hepatitis C infection is caused by the hepatitis C virus (HCV). People who may be at risk for hepatitis C are those who:
Hepatitis C has an acute and chronic form. Most people who are infected with the virus develop chronic hepatitis C.
About 1.5% of the U.S. population is infected with HCV.
Most people who were recently infected with hepatitis C do not have symptoms. About 10% have jaundice that gets better.
Of people who get infected with HCV, most develop chronic HCV infection. Usually there are no symptoms.
If the infection has been present for many years, the liver may be permanently scarred, a condition called cirrhosis. In many cases, there may be no symptoms of the disease until cirrhosis has developed.
The following symptoms could occur with hepatitis C infection:
The following tests are done to help diagnose hepatitis C:
The following tests are done to identify and monitor liver damage from hepatitis C:
Liver biopsy can show how much damage has been done to the liver.
The goals of HCV treatment are to remove the virus from the blood and reduce the risk of cirrhosis and liver cancer that can result from long-term HCV infection.
Many patients with hepatitis C benefit from treatment with medications. The most common medications are a combination of pegylated interferon alfa and ribavirin, an antiviral medication.
These medications have a number of side effects, and patients must be watched closely. Symptoms include:
See: Cirrhosis for information about treating more severe liver damage caused by hepatitis C.
Patients who develop cirrhosis or liver cancer may be candidates for a liver transplant.
People with hepatitis C should also:
You can often ease the stress of illness by joining a support group of people who share common experiences and problems. See liver disease - resources.
Most people with hepatitis C infection have the chronic form.
Patients with genotypes 2 or 3 are more likely to respond to treatment than patients with genotype 1.
The chance of removing the hepatitis C virus from the blood with treatment is over 90% for some people. Even if treatment does not remove the virus, it can reduce the chance of severe liver disease.
Many doctors use the term "sustained virologic response" rather than "cure" when the virus is removed from the blood, because it is not known whether this will last a person's entire life.
Hepatitis C is one of the most common causes of chronic liver disease in the United States today. People with this condition may have:
Hepatitis C usually comes back after a liver transplant, which can lead to cirrhosis of the new liver.
Call your health care provider if:
Avoid contact with blood or blood products whenever possible. Health care workers should follow precautions when handling blood and bodily fluids.
Do not inject illicit drugs, and especially do not share needles with anyone. Be careful when getting tattoos and body piercings.
Sexual transmission is very low among stable, monogamous couples. A partner should be screened for hepatitis C. If the partner is negative, the current recommendations are to make no changes in sexual practices.
People who have sex outside of a monogamous relationship should practice safer sex behaviors to avoid hepatitis C as well as sexually transmitted diseases, including HIV and hepatitis B.
Currently there is no vaccine for hepatitis C.
Ghany MG, Strader DB, Thomas DL, Seeff LB. American Association for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology. 2009;49:1335-1374.
Jou JH, Muir AJ. In the clinic. Hepatitis C. Ann Intern Med. 2008;148:ITC6-1-ITC6-16.
O'Leary JG, Davis GL. Hepatitis C. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, Pa: Saunders Elsevier; 2010:chap 79.